Overview
Pancreatoduodenectomy is a complex surgical procedure associated with a high risk of surgical-site infections (SSIs) 1. These infections can significantly increase patient morbidity and mortality 1.Diagnosis
Surgical-site infections are a primary concern following pancreatoduodenectomy 1.
Major surgical complications are graded using systems such as Clavien-Dindo grade III or higher 1.Management
Piperacillin/tazobactam prophylaxis is associated with reduced incidences of SSIs and major surgical complications compared to traditional antibiotic prophylaxis 1.
Specific outcomes include significantly reduced superficial surgical-site infections with piperacillin/tazobactam 1.Key Recommendations
Piperacillin/tazobactam should be considered for surgical prophylaxis during pancreatoduodenectomy due to its association with reduced surgical-site infections and major surgical complications 1. (Evidence: Strong)
Traditional antibiotic prophylaxis strategies may be inadequate for pancreatoduodenectomy given the increased incidence of SSIs 1. (Evidence: Strong)References
1 Kumar J, Reccia I, Carneiro A, Podda M, Virdis F, Machairas N et al.. Piperacillin/tazobactam for surgical prophylaxis during pancreatoduodenectomy: meta-analysis. BJS open 2024. link