Pulmonary toxicity

Overview

Diagnosis

Management

Special Populations

Key Recommendations

References

Showing 100 most recent of 767 indexed papers.

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Comparative analysis of the characteristics and trends of adverse drug reaction reports from patients in Japan and the Japanese Adverse Drug Event Report database. British journal of clinical pharmacology 2026. link 7 Xiao S, Tong M, Ren J, Bai Y, Xu J, Otsuki K et al.. Cardiac glycosides toxicity: Mechanisms and mitigation strategies in recent studies. Chemico-biological interactions 2026. link 8 Anderson J, Rushton WF, Burleson SL, Thompson M, Atti S, Griesmer KB. Calcium channel antagonists and point-of-care ultrasound: A case series. The American journal of emergency medicine 2026. link 9 Xiang Y, Ji Q, Pang Y, Zhang X, Wang J, Liu Y et al.. Developmental Multi-Organ Toxicity in Zebrafish Exposed to 1, 2-Dichloroethane. Journal of applied toxicology : JAT 2026. link 10 Alipanah H, Sohrabi Z, Sayadi M, Nematollahi A, Nejati R. Probiotic Lactobacillus Strains Mitigate Chlorpyrifos-Induced Lung and Heart Toxicity in Rats via Anti-inflammatory and Antioxidant Mechanisms. 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Schisandrol A induces cardiac developmental toxicity in zebrafish (Danio rerio) via disruption of calcium homeostasis, oxidative stress, and apoptosis. Toxicology and applied pharmacology 2026. link 16 Zhao B, Chang Z, Huo M. FEAOF: A transferable framework applied to prediction of hERG-related cardiotoxicity. Computational biology and chemistry 2026. link 17 Song J, Liu S, Shi X, Gao J, Spanos M, Zhou Q et al.. Biomarkers for cancer therapy-related cardiovascular toxicity. International review of cell and molecular biology 2026. link 18 Avagimyan AA, Pogosova N, Fogacci F, Urazova O, Djndoyan Z, Mirzoyan L et al.. Pharmacological prevention in cardio-oncology: from bench-to-bedside. Heart failure reviews 2025. link 19 Fikri F, Miftahurrohmah A, Pratama MS, Qosdina DF, Sya'ban GF, Maslamama ST et al.. Astaxanthin improves hematology, interleukin-6, and tumor necrosis factor-α in the albino rats' kidney model of dexamethasone toxicity. Open veterinary journal 2025. link 20 Griesmer KB, Thompson M, Miller B, Zhai G, Raper J, Bloom A. Combining Immersive Simulation with a Collaborative Procedural Training on Local Anesthetic Systemic Toxicity and Fascia Iliaca Compartment Block: A Pilot Study. The western journal of emergency medicine 2025. link 21 Curtain NE, Gugelmin-Almeida D. Addressing human factors in the recognition and management of local anaesthetic systemic toxicity. Journal of perioperative practice 2025. link 22 Tripathi NK, Ramaiah L, Arndt T, Cregar L, Adedeji AO, Meyer D et al.. Toxicologic Pathology Forum: Opinion on Qualitative Severity Descriptors to Express Magnitude of Changes in Clinical Pathology Endpoints in Nonclinical Toxicity Studies. Toxicologic pathology* 2025. link 23 Abel O, Press Y. An Older Man with Clonus, Rigidity, Hyperreflexia, and Hand Tremors. Journal of pain & palliative care pharmacotherapy 2025. link 24 Ahmad S, Hassan A, Rashid S, Sudhir V. Severe metabolic acidosis with elevated lactate and multi-organ dysfunction secondary to ethylene glycol toxicity. BMJ case reports 2025. link 25 Alemseged NM, Ibrahim MA, Sheikabdullahi MA. Colocynth induced multiorgan toxicity: a case report. Journal of medical case reports 2025. link 26 Schwenk ES, Sneyd JR, Wu CL. The state of local anaesthetic systemic toxicity in 2025: the emergence of lidocaine as our next challenge. British journal of anaesthesia 2025. link 27 Lhamo Y, Purohit K, Singh S, Chopra D, Bharti M. Pattern, severity, and preventability of adverse drug reactions from a Northern Indian tertiary care facility: A retrospective analysis. The International journal of risk & safety in medicine 2025. link 28 Shi Y, Yao K, Zhao J, Yue Y, Wu H. Gastrointestinal toxicity of antibody-drug conjugates: a pharmacovigilance study using the FAERS database. BMC pharmacology & toxicology 2025. link 29 Shahid I, Lancelot E. Symptoms Associated With Gadolinium Exposure: Different Patterns and Rates Between Linear and Macrocyclic Gadolinium-Based Contrast Agents. Investigative radiology 2025. link 30 Nyame L, Xue H, Yu J, Fiagbey EDK, Thomford KP, Du W. Characteristics and trends in adverse drug reactions in Ghana-evidence of spontaneous reports, 2005-2021. Naunyn-Schmiedeberg's archives of pharmacology 2025. link 31 Imbrici P, De Bellis M, Liantonio A, De Luca A. Investigating the Benefit-Risk Profile of Drugs: From Spontaneous Reporting Systems to Real-World Data for Pharmacovigilance. Methods in molecular biology (Clifton, N.J.) 2025. link 32 Fettiplace MR, Weinberg G, Chiang C, Nixon HC, Gitman M. Contemporary local anaesthetic-associated adverse events and mortality: a pharmacovigilance analysis of a US reporting system. British journal of anaesthesia 2025. link 33 Kini P, Reddy MS, Ganachari MS. From reaction to reporting: Impact of pharmacovigilance in a tertiary care hospital setting at Belagavi. The International journal of risk & safety in medicine 2025. link 34 Logan V, Hughes D, Turner A, Carter N, Jordan S. Methods for identifying adverse drug reactions in primary care: A systematic review. PloS one 2025. link 35 Wu L, Fang H, Qu Y, Xu J, Tong W. Leveraging FDA Labeling Documents and Large Language Model to Enhance Annotation, Profiling, and Classification of Drug Adverse Events with AskFDALabel. Drug safety 2025. link 36 Jeong E, Su Y, Li L, Chen Y. Discovering Severe Adverse Reactions From Pharmacokinetic Drug-Drug Interactions Through Literature Analysis and Electronic Health Record Verification. Clinical pharmacology and therapeutics 2025. link 37 Ding G, Ding J. Research and practice on key drug safety monitoring under the normalization of centralized procurement: A case study of 13 selected drugs in a Province. Medicine 2025. link 38 Crisafulli S, Bate A, Brown JS, Candore G, Chandler RE, Hammad TA et al.. Interplay of Spontaneous Reporting and Longitudinal Healthcare Databases for Signal Management: Position Statement from the Real-World Evidence and Big Data Special Interest Group of the International Society of Pharmacovigilance. Drug safety 2025. link 39 De Pretis F, van Gils M, Varheenmaa M, Tiihonen M, Forsberg MM. Innovative approaches to collecting, aggregating, and analyzing adverse drug events in smart hospitals. The International journal of risk & safety in medicine 2025. link 40 Lee SJ, Kim E, Jeong Y, Youm JB, Kim HK, Han J et al.. Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids. Ecotoxicology and environmental safety 2025. link 41 Fu J, Cheng L, Zhang J, Sun R, Yu M, Wu M et al.. Isoliquiritin targeting m5C RNA methylation improves mitophagy in doxorubicin-induced myocardial cardiotoxicity. Phytomedicine : international journal of phytotherapy and phytopharmacology 2025. link 42 Wang J, Yuan Q, Hu W, Ye Z, Zhang L, Wang Z et al.. 3-Chloro-1,2-Propanediol Exposure Induces Cardiotoxicity and Behavioural Abnormalities in Zebrafish Embryos. Environmental toxicology 2025. link 43 Kuang Z, Kong M, Yan N, Ma X, Wu M, Li J. Precision Cardio-oncology: Update on Omics-Based Diagnostic Methods. Current treatment options in oncology 2024. link 44 Rudra R, Probert A, Ceasar J, Romanoski N. Local anesthetic systemic toxicity: An effort to identify knowledge gaps across specialties. PM & R : the journal of injury, function, and rehabilitation 2024. link 45 Arndt T, Keresztes M, Olivier B, Boone L, Chanut F, Ennulat D et al.. Considerations for the Identification and Conveyance of Clinical Pathology Findings in Preclinical Toxicity Studies: Results From the 9th ESTP International Expert Workshop. Toxicologic pathology 2024. link 46 Yalcin N, van den Anker J, Samiee-Zafarghandy S, Allegaert K. Drug related adverse event assessment in neonates in clinical trials and clinical care. Expert review of clinical pharmacology 2024. link 47 Zhang J, Wang R, Qu G, Ma J, Wang Y, Zhang D et al.. Acute fatal chromium toxicity: A case report of electroplating water ingestion. Legal medicine (Tokyo, Japan) 2024. link 48 Bingul E, Bulut S, Mammadov R, Cicek B, Dogru TE, Suleyman H et al.. Effect of ethyl acetate extract from Usnea longissima on chemotherapy-associated multiple organ dysfunction in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024. link 49 Painter JL, Haguinet F, Powell GE, Bate A. Ontology-based Semantic Similarity Measures for Clustering Medical Concepts in Drug Safety. AMIA ... Annual Symposium proceedings. AMIA Symposium 2024. link 50 Kauppila M, Backman JT, Niemi M, Lapatto-Reiniluoto O. Drug-related deaths in a university hospital: Comparison to previous decades. Basic & clinical pharmacology & toxicology 2024. link 51 Kontsioti E, Maskell S, Anderson I, Pirmohamed M. Identifying Drug-Drug Interactions in Spontaneous Reports Utilizing Signal Detection and Biological Plausibility Aspects. Clinical pharmacology and therapeutics 2024. link 52 Alloush R, van Lint J, van Marum RJ, Hermens WWAJJ, Jessurun NT. Hospital registration of adverse drug reactions in electronic health records: importance and contribution to pharmacovigilance. Expert opinion on drug safety 2024. link 53 Morris R, Ali R, Cheng F. Drug Repurposing Using FDA Adverse Event Reporting System (FAERS) Database. Current drug targets 2024. link 54 Sartori D, Aronson JK, Erlanson N, Norén GN, Onakpoya IJ. A Comparison of Signals of Designated Medical Events and Non-designated Medical Events: Results from a Scoping Review. Drug safety 2024. link 55 Zatovkaňuková P, Slíva J. Diverse pharmacovigilance jurisdiction-The right way for global drug safety?. European journal of clinical pharmacology 2024. link 56 Trenque A, Rabiaza A, Fedrizzi S, Chretien B, Sassier M, Morello R et al.. Evaluation of a simplified pharmacovigilance tool for general practitioners: 5 years of insight. Scientific reports 2024. link 57 Xu X, Riviere JE, Raza S, Millagaha Gedara NI, Ampadi Ramachandran R, Tell LA et al.. (no title). Expert opinion on drug metabolism & toxicology 2024. link 58 Tanaka Y, Tanaka M, Miyazawa H, Terashima R, Miyazawa M, Ikuma M et al.. Postmarket safety communications on drugs approved in Japan: A 25-year analysis. Clinical and translational science 2024. link 59 Destere A, Merino D, Lavrut T, Rocher F, Viard D, Drici MD et al.. Drug-induced cardiac toxicity and adverse drug reactions, a narrative review. Therapie 2024. link 60 Espinosa J, Bassett R, Lucerna A, Finn D. Hawthorne root (Crataegus mexicana) toxicity. The American journal of emergency medicine 2024. link 61 Yang Y, Tao Y, Yi X, Zhong G, Gu Y, Cui Y et al.. Crosstalk between aryl hydrocarbon receptor and Wnt/β-catenin signaling pathway: Possible culprit of di (2-ethylhexyl) phthalate-mediated cardiotoxicity in zebrafish larvae. The Science of the total environment 2024. link 62 Couderc S, Gabriel A, Decheiver S, N'Zoué Kanga S, Fikanni A, Flint H et al.. A Massive Venlafaxine Intoxication: Evolution of Cardiac Toxicity with Venlafaxine and O-Desmethylvenlafaxine Elimination Kinetics: A Grand Round. Therapeutic drug monitoring 2024. link 63 Waxer JF, Wong K, Modiri A, Charpentier AM, Moiseenko V, Ronckers CM et al.. Risk of Cerebrovascular Events Among Childhood and Adolescent Patients Receiving Cranial Radiation Therapy: A PENTEC Normal Tissue Outcomes Comprehensive Review. International journal of radiation oncology, biology, physics 2024. link 64 Montastruc JL. Fatal adverse drug reactions in children: A descriptive study in the World Health Organization pharmacovigilance database, 2010-2019. British journal of clinical pharmacology 2023. link 65 Živanović D, Mijatović Jovin V, Javorac J, Samojlik I, Rašković A, Jevtić M et al.. PHARMACOVIGILANCE IN SERBIA: A TEN-YEAR PHARMACOEPIDEMIOLOGIC ANALYSIS. Acta clinica Croatica 2023. link 66 Lu Z, Suzuki A, Wang D. Statistical methods for exploring spontaneous adverse event reporting databases for drug-host factor interactions. BMC medical research methodology 2023. link 67 Mhaidat NM, Alshogran OY, Altawalbeh SM, Jaber JM, Banat HA, Ahmad DS et al.. Patterns of adverse drug reactions in Jordan: a retrospective analysis of the National Pharmacovigilance Data Registry (2015-2021). Expert opinion on drug safety 2023. link 68 Steyn H. Profile of adverse drug reaction reports in South Africa: An analysis of VigiBase® for the year 2017. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 2023. link 69 Wilde JT, Springs S, Wolfrum JM, Levi R. Development and Application of a Data-Driven Signal Detection Method for Surveillance of Adverse Event Variability Across Manufacturing Lots of Biologics. Drug safety 2023. link 70 Darke S, Duflou J, Peacock A, Chrzanowska A, Farrell M, Lappin J. Clinical characteristics of fatal cocaine toxicity in Australia, 2000-2021. Drug and alcohol review 2023. link 71 Luo Q, Tang S, Xiao X, Wei Y, Cheng B, Huang Y et al.. Benomyl-induced development and cardiac toxicity in zebrafish embryos. Environmental science and pollution research international 2023. link 72 Du W, Wang X, Wang L, Wang M, Liu C. Avermectin induces cardiac toxicity in early embryonic stage of zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2023. link 73 Park J, Hong T, An G, Park H, Song G, Lim W. Triadimenol promotes the production of reactive oxygen species and apoptosis with cardiotoxicity and developmental abnormalities in zebrafish. The Science of the total environment 2023. link 74 Lee SH, Ok SH, Ahn SH, Sim G, Kim HJ, Kim M et al.. Lipid emulsion inhibits the cardiac toxicity caused by chloroquine via inhibition of reactive oxygen species production. Korean journal of anesthesiology 2023. link 75 Crulli B, Dines AM, Blanco G, Giraudon I, Eyer F, Liechti ME et al.. Novel psychoactive substances-related presentations to the emergency departments of the European drug emergencies network plus (Euro-DEN plus) over the six-year period 2014-2019. Clinical toxicology (Philadelphia, Pa.) 2022. link 76 Ramesh P, Demertzi M, Suraweera P. Knowledge, attitude and practice on usage and toxicity of local anaesthetic agents (LA) amongst health care professionals in obstetrics and gynaecology. 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The Impact of Mandatory Reporting of Non-Serious Safety Reports to EudraVigilance on the Detection of Adverse Reactions. Drug safety 2022. link 87 Dhodapkar MM, Shi X, Ramachandran R, Chen EM, Wallach JD, Ross JS. Characterization and corroboration of safety signals identified from the US Food and Drug Administration Adverse Event Reporting System, 2008-19: cross sectional study. BMJ (Clinical research ed.) 2022. link 88 Zelko IN, Taylor BS, Das TP, Watson WH, Sithu ID, Wahlang B et al.. Effect of vinyl chloride exposure on cardiometabolic toxicity. Environmental toxicology 2022. link 89 Han L, Xia Q, Zhang L, Zhang X, Li X, Zhang S et al.. Induction of developmental toxicity and cardiotoxicity in zebrafish embryos/larvae by acetyl-11-keto-β-boswellic acid (AKBA) through oxidative stress. Drug and chemical toxicology 2022. link 90 Yang R, Tan C, Najafi M. Cardiac inflammation and fibrosis following chemo/radiation therapy: mechanisms and therapeutic agents. 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Effects of polypharmacy on the prevalence of adverse drug events resulting in outpatient visits and hospitalization. Die Pharmazie 2021. link 96 Wadhwa D, Kumar K, Batra S, Sharma S. Automation in signal management in pharmacovigilance-an insight. Briefings in bioinformatics 2021. link 97 Schotland P, Racz R, Jackson DB, Soldatos TG, Levin R, Strauss DG et al.. Target Adverse Event Profiles for Predictive Safety in the Postmarket Setting. Clinical pharmacology and therapeutics 2021. link 98 Segec A, Slattery J, Morales DR, Januskiene J, Kurz X, Arlett P. Does additional monitoring status increase the reporting of adverse drug reactions? An interrupted time series analysis of EudraVigilance data. Pharmacoepidemiology and drug safety 2021. link 99 Khouri C, Petit C, Tod M, Lepelley M, Revol B, Roustit M et al.. Adverse drug reaction risks obtained from meta-analyses and pharmacovigilance disproportionality analyses are correlated in most cases. 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