Clinical Presentation
[PMID:2368963] Acute exposure to 0.4 ppm ozone resulted in a substantial increase in polymorphonuclear neutrophils (PMN) in nasal lavages immediately post-exposure (7.7-fold increase) and at 18 hours post-exposure (6.1-fold increase), paralleled by a similar increase in bronchoalveolar lavage (6.0-fold increase) at 18 hours.
Diagnosis
[PMID:2368963] Although there was a qualitative correlation between upper and lower respiratory tract PMN counts in ozone-exposed subjects, nasal lavage PMN counts showed a strong potential as a useful and less invasive biomarker for detecting lower lung inflammation post-exposure.
Management
[PMID:2368963] Given the significant increase in PMN and albumin levels in both nasal lavages and bronchoalveolar lavage post-ozone exposure, monitoring nasal lavage PMN levels could provide insights into the effectiveness of management interventions aimed at reducing respiratory inflammation.
References
1 Graham DE, Koren HS. Biomarkers of inflammation in ozone-exposed humans. Comparison of the nasal and bronchoalveolar lavage. The American review of respiratory disease 1990. link
1 papers cited of 5 indexed.