Overview
Thyrotropin (TSH) serum levels have been investigated for their potential to characterize major depressive disorder (MDD) phenotypes. Conflicting data exist regarding TSH levels in first-episode drug-naïve MDD patients compared to healthy subjects 1.Diagnosis
TSH levels may be different between first-episode drug-naïve MDD patients and healthy subjects, though data are conflicting 1.
Higher TSH levels are associated with an increased risk of suicide attempt in MDD patients 1.Management
No management strategies for isolated thyrotropin deficiency are discussed in the provided abstracts.Special Populations
No information on special populations is available in the provided abstracts.Key Recommendations
Higher TSH levels are related to an increased risk of suicide attempt in major depressive disorder patients 1. (Evidence: Moderate)
Data are conflicting regarding whether TSH levels differ between first-episode drug-naïve MDD patients and healthy subjects 1. (Evidence: Moderate)References
1 Gatta E, Maltese V, Ugoccioni M, Silvestrini I, Corvaglia S, Vetrugno S et al.. Could thyrotropin serum level characterize major depressive disorder phenotype? A systematic review and meta-analysis. Journal of endocrinological investigation 2026. link