Overview
Structural abnormalities in the hippocampus are associated with conditions such as posttraumatic stress disorder (PTSD). These abnormalities can manifest as smaller regional brain volumes in areas crucial for fear and memory processing 1.Diagnosis
Smaller regional brain volumes in the hippocampus are observed in patients with PTSD 1.
Voxel-based morphometry (VBM) meta-analysis using T1-weighted structural neuroimaging scans can identify these abnormalities 1.Management
No management strategies for hippocampal structural abnormalities are discussed in the provided abstracts.Special Populations
No information on special populations is provided in the abstracts.Key Recommendations
Patients with PTSD exhibit smaller regional brain volumes in the hippocampus, a region associated with fear and memory processing 1. (Evidence: Moderate)
Voxel-based morphometry (VBM) meta-analysis of structural neuroimaging data can identify regional differences in brain volumes in PTSD patients 1. (Evidence: Moderate)
Widespread, regional differences in brain volumes, including the hippocampus, are observed in PTSD patients, with greater deficits potentially reflecting more severe symptoms 1. (Evidence: Moderate)References
1 See CRZ, Si S, Baird CL, Haswell CC, Hussain A, Olff M et al.. A whole-brain voxel-based analysis of structural abnormalities in PTSD: An ENIGMA-PGC study. European psychiatry : the journal of the Association of European Psychiatrists 2025. link