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Neurosurgery9 papers

Degeneration of thoracolumbar intervertebral disc

Last edited: 4/16/2026

Overview

Thoracolumbar intervertebral disc degeneration involves the deterioration of discs in the mid-to-lower back, often leading to spinal cord compression and neurological deficits in both humans and animals, notably dogs 1.

Diagnosis

  • Neurological examination to assess motor function, sensory deficits, and reflexes 1.
  • Imaging studies such as MRI or CT scans to visualize disc herniation and spinal cord compression 1.
  • Pain assessment using composite pain scales and sensory testing devices 1.
  • Management

  • First-line treatments:
  • - Multimodal analgesia including opioids (methadone subcutaneously or transdermal fentanyl) 1.
  • Adjunctive treatments:
  • - Early physiotherapy and mobilization to prevent complications 1. - Surgical intervention for severe cases with significant neurological deficits 1.

    Special Populations

  • Dogs: Subcutaneous methadone and transdermal fentanyl provide adequate postoperative analgesia without necessitating intravenous access, facilitating early mobilization 1.
  • Key Recommendations

  • Consider subcutaneous methadone or transdermal fentanyl for postoperative pain management in dogs post-thoracolumbar disc surgery to avoid the need for intravenous catheters 1 (Evidence: Moderate).
  • Utilize multimodal pain assessment tools in dogs postoperatively to evaluate pain effectively 1 (Evidence: Moderate).
  • Facilitate early physiotherapy and mobilization in dogs post-surgery to enhance recovery 1 (Evidence: Expert opinion).
  • References

    1 Schütter AF, Verhoeven A, Tünsmeier J, Kästner SBR. Subcutaneous methadone is not different than transdermal fentanyl for postoperative analgesia in dogs with thoracolumbar disc disease, a prospective, randomised, blinded clinical study. BMC veterinary research 2025. link

    Original source

    1. [1]

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