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Metastatic malignant neoplasm to urethra

Last edited: 4/10/2026

Overview

Metastatic malignant neoplasm to the urethra is a rare condition where cancer originating elsewhere in the body spreads to the urethra. This can lead to various symptoms depending on the location and extent of the metastasis.

Diagnosis

Management

  • Transurethral resection of the prostate (TURP) is a surgical procedure that can be used to manage symptoms associated with urethral obstruction, though it is primarily indicated for benign prostatic hyperplasia 1.
  • TURP has demonstrated significant improvements in International Prostate Symptom Score (IPSS), peak flow (Qmax), and postvoid residual urine (PVR) 1.
  • Complication rates for TURP are generally low, including TURP syndrome (2%), bleeding (8%), and need for blood transfusion (6%) 1.
  • Significant heterogeneity in outcomes, particularly for clot evacuation, has been observed across different geographical regions, suggesting a lack of standardization in TURP procedures 1.
  • Special Populations

    Key Recommendations

  • Transurethral resection of the prostate (TURP) is considered the gold-standard surgical treatment for benign prostatic hyperplasia, offering uniform symptomatic improvements despite variations in worldwide results 1. (Evidence: Strong)
  • References

    1 Porto JG, Bhatia AM, Bhat A, Suarez Arbelaez MC, Blachman-Braun R, Shah K et al.. Transurethral resection of the prostate across continents: a meta-analysis evaluating quality of gold standard in the twenty-first century. World journal of urology 2025. link

    Original source

    1. [1]
      Transurethral resection of the prostate across continents: a meta-analysis evaluating quality of gold standard in the twenty-first century.Porto JG, Bhatia AM, Bhat A, Suarez Arbelaez MC, Blachman-Braun R, Shah K et al. World journal of urology (2025)

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