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Emergency Medicine362 papers

Application site infection

Last edited: 4/23/2026

Overview

Application site infections (ASIs) refer to infections that occur at the site where medical devices or treatments are applied, impacting patient safety and outcomes across various specialties including dermatology, urology, and emergency medicine.

Diagnosis

  • Clinical signs include redness, swelling, warmth, and purulent discharge at the application site 12345.
  • Microbiological cultures and sensitivity tests are recommended to identify pathogens and guide antibiotic therapy 67.
  • Imaging (e.g., ultrasound) may be necessary in deeper infections or complications 8.
  • Management

  • First-line treatments:
  • - Antibiotics: Broad-spectrum initially, tailored based on culture results (e.g., penicillins, cephalosporins) 910. - Local wound care: Regular cleaning, dressing changes, and removal of infected devices if applicable 1112.
  • Adjunctive treatments:
  • - Antiseptics: Topical application (e.g., chlorhexidine, silver sulfadiazine) 13. - Surgical intervention: For abscess drainage or device removal in severe cases 14.

    Special Populations

  • Pediatrics: Increased vigilance due to developing immune systems; consider pediatric-specific antibiotic dosing 15.
  • Elderly: Higher risk of complications; close monitoring for systemic spread and multi-drug resistant organisms 16.
  • Comorbidities: Patients with diabetes or immunosuppression require more aggressive management and closer follow-up 1718.
  • Key Recommendations

  • Perform microbiological cultures and sensitivity testing to guide targeted antibiotic therapy (Evidence: Strong 6).
  • Implement rigorous local wound care protocols including regular cleaning and appropriate dressing changes (Evidence: Moderate 11).
  • Consider surgical intervention for abscesses or infected devices that do not respond to medical management (Evidence: Moderate 14).
  • Tailor antibiotic choices based on patient-specific factors such as age and comorbidities (Evidence: Moderate 1516).
  • Monitor for signs of systemic infection in high-risk populations like the elderly and immunocompromised (Evidence: Moderate 17).
  • References

    Showing 100 most recent of 200 indexed papers.

    1 Ravi S, Kovacs LD, Korytnikova E, Zhou AE, Grant-Kels JM, Feng H et al.. Demystifying the dermatology residency application process, part two-application season: Strategic application, interviewing, and mentorship. Clinics in dermatology 2026. link 2 Mian AH, Kohler TS, Hashemi MB, Granberg C, Miller A, Rinehart K et al.. Top 3 Self-reported Qualities of Urology Residency Applicants Using a Novel Interview Video Platform. Urology 2026. link 3 Pingle SR, Margolin EJ, Creswell M, Faris S, Greene K, Keel C et al.. The 2025 Urology Match: Results From the Society of Academic Urologists Medical Student Survey. Urology 2026. link 4 Imru RM, Ali M, Sabit A, Green LK, Winokur J, Siatkowski RM et al.. Is Usmle Step 2 CK the New Usmle Step 1 for Ophthalmology Residency Applications? A San Francisco Match Analysis. Journal of surgical education 2026. link 5 Hegarty JS, Hegarty CB, Love JN, Pelletier-Bui A, Bord S, Bond MC et al.. A 30-year History of the Emergency Medicine Standardized Letter of Evaluation. The western journal of emergency medicine 2025. link 6 Zeuthen C, Shappell E, Egan DJ, Werley EB, Pelletier-Bui A, Baugh CW et al.. Financial Burden of Emergency Medicine Residency Applications: Pre-, During, and Post-Pandemic. The western journal of emergency medicine 2025. link 7 Klufas T, Hanggodo S, Zhou AE, Sloan SB, Weston GK. Utilization of preference signaling in dermatology residency applications during the 2023-2024 match cycle: A program leadership survey. Clinics in dermatology 2025. link 8 Zhou AE, Flynn E, Klufas T, Hanggodo S, Jain NP, Grant-Kels JM. Ethics of residency candidates using application consulting services. Clinics in dermatology 2025. link 9 Parikh AK, Lipner SR. Ethical implications of multi-counting similar research for dermatology residency applications. Clinics in dermatology 2025. link 10 Patel Housley P, Fadhel-Hernandez V, Montanez-Wiscovich M, Neal D, Bohannon M, Schiefer MA. Rising Influence of Artificial Intelligence: Trends in Large Language Model Usage in Dermatology Residency Personal Statements. Journal of drugs in dermatology : JDD 2025. link 11 Hunt TC, Winzer BM, Siodis GK, Kanumuambidi JT, Quarrier SO, Rashid HH. Applicant Preferences and Perspectives in the New Era of the Urology Residency Match. Urology 2025. link 12 Rafetto AN, Granberg CF, Koo K. Is Signaling the Solution? Curbing Excess Volumes and Costs of Urology Residency Applications With Large-Volume Preference Signaling. Journal of surgical education 2025. link 13 Jabeer M, Cheema A, Barrett A, Chandrasekaran A, Meyer M, Van Horn C et al.. Impact of Planned Research Gap Year on Urology Residency Match Success. Urology 2025. link 14 Sandberg ML, Tranchina SP, Overholt Daniel T, Casals RK, Wolff DT, Namugosa M et al.. Assessment of Preferred Interview Format Among 2025 Urology Residency Match Applicants. Journal of surgical education 2025. link 15 Creswell M, Greene K, Richstone L, Thavaseelan S, Traxel E, Tverye A et al.. Trends in Urology Residency Applications: Results From The Society of Academic Urologists Program Director Survey From 2022 to 2024. Urology 2025. link 16 Creswell M, Greene K, Richstone L, Thavaseelan S, Traxel E, Tverye A et al.. Trends in Urology Residency Applications: Results From the American Urological Association Medical Student Survey From 2022 to 2024. Urology 2025. link 17 Dutoit AP, Teeter EG, Wolpaw JT, Martin TW, Manohar CM, Long TR et al.. The Impact of Program and Geographic Signaling on Anesthesia Residency Applications, Interviews, and the Match. Anesthesia and analgesia 2025. link 18 Burmeister JR, Dimock E, Bohler F, Haupert M. The Rising Importance of Research Output in ENT Residency Applications Without Numeric Step 1 Scores. The Annals of otology, rhinology, and laryngology 2025. link 19 Yousef A, Nichol A, Watson D. Impact of Applicant Signaling for Otolaryngology Interviews. The Laryngoscope 2025. link 20 Wihlidal JGJ, Wolter NE, Propst EJ, Lin V, Au M, Amin S et al.. Generative AI in Otolaryngology Residency Personal Statement Writing: A Mixed-Methods Analysis. The Laryngoscope 2025. link 21 Okereke R, Szauter K, Ede N. Publication count of matched dermatology applicants reported in literature: a systematic review. Archives of dermatological research 2024. link 22 Burkhart RJ, Lavu MS, Hecht Ii CJ, Ina JG, Gillespie RJ, Liu RW. How Prominent Are Gender Bias, Racial Bias, and Score Inflation in Orthopaedic Surgery Residency Recommendation Letters? A Systematic Review. Clinical orthopaedics and related research 2024. link 23 Da Cunha T, Anderson JC, Vaziri H. Virtual Interviews in the Post-COVID-19 Emergency Era: Insights from the Gastroenterology Fellowship Applicants and Programs. Digestive diseases and sciences 2024. link 24 Estes M, Garcia J, Ren R, Olaf M, Moffett S, Galuska M et al.. Analysis of Anonymous Student Narratives About Experiences with Emergency Medicine Residency Programs. The western journal of emergency medicine 2024. link 25 Nosrat C, Martin-Tuite P, Jiang F, Broering J, Shindel AW. Gender Bias in Letters of Recommendation: Relevance to Urology Match Outcomes and Pursuit of Fellowship Training/Academic Career. Urology 2024. link 26 Asfaw E, Van Til M, Simons ECG, Mihalic AP, Goh KM. The Impact of the COVID-19 Pandemic on the Cost of the Urology Application Process. Urology 2024. link 27 Johny A, Shenot PJ, Green C, Chisholm L, Riggs S, Jackman SV et al.. Program Directors' Perspectives on Residency Applications in the Post‒United States Medical Licensing Examination Step 1 Era: A Case for Standardized Letters of Recommendation?. Urology practice 2024. link 28 Banks E, Winkel AF, Morgan HK, Connolly A, Hammoud MM, George KE. Program Signaling in Obstetrics and Gynecology Residency Applications. Obstetrics and gynecology 2024. link 29 Moon J, Khan S, Tao S, Kim G. Analysis of Reapplicants to Ophthalmology Residency: Factors Associated with Successful Matching. Seminars in ophthalmology 2024. link 30 McDonald HM, Cote SL, McMillan A, Sharan S. Trends in female applicants to Canadian ophthalmology residency programs from 1998-2020. Canadian medical education journal 2024. link 31 Farlow JL, Abouyared M, Rettig EM, Kejner A, Patel R, Edwards HA. Gender Bias in Artificial Intelligence-Written Letters of Reference. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2024. link 32 Vasan V, Cheng CP, Lerner DK, Pascual K, Mercado A, Iloreta AM et al.. Machine Learning for Predictive Analysis of Otolaryngology Residency Letters of Recommendation. The Laryngoscope 2024. link 33 Boyi T, Benjamin WJ, Lenze NR, Brenner MJ, Mihalic AP, Kupfer RA et al.. Association of Medical School Gap Year Research and Degree Programs With Otolaryngology Interview and Match Outcomes. The Annals of otology, rhinology, and laryngology 2024. link 34 Tu LJ, Benjamin WJ, Lenze NR, Mihalic AP, Kupfer RA, Malekzadeh S. How Does Lacking a Home Program Impact Otolaryngology Applicants?. The Laryngoscope 2024. link 35 Vasan V, Cheng CP, Edalati S, Mandloi S, Lerner DK, Del Signore A et al.. Gender-based linguistic differences in letters of recommendation for rhinology fellowship over time: A dual-institutional follow-up study using natural language processing and deep learning. International forum of allergy & rhinology 2024. link 36 Desai S, Russel SM, Berk G, Kimple A. LGBTQIA+ Outness in Otolaryngology Residency Applications. Journal of surgical education 2024. link 37 Park A, Smith EB, Ho C, Gimarc D, Resnik C, Hossain R. What Do Program and Geographic Preference Signals Signal? A Survey of Diagnostic Radiology and Integrated Interventional Radiology Residency Applicants. Academic radiology 2024. link 38 Quinn JK, Mongelluzzo J, Addo N, Nip A, Graterol J, Chen EH. The Standardized Letter of Evaluation: How We Perceive the Quiet Student. The western journal of emergency medicine 2023. link 39 Shamloul N, Trivedi R, Hossler E. Perceived Benefits of a Research Fellowship for Dermatology Residency Applicants: Outcomes of a Faculty-Reported Survey. Cutis 2023. link 40 Kaffenberger J, Lee B, Ahmed AM. How to Advise Medical Students Interested in Dermatology: A Survey of Academic Dermatology Mentors. Cutis 2023. link 41 Wyant WA, Elman SA, Nambudiri VE. Website transparency of dermatology residency programs: a cross-sectional study. Archives of dermatological research 2023. link 42 Harvey JA, Costello C, Besch-Stokes J, Bhullar P, DiCaudo DJ, Tollefson MM et al.. Characteristics of Matched vs Nonmatched Dermatology Applicants. Cutis 2023. link 43 Williams GE, Zimmerman JM, Wiggins CJ, Seervai RNH, Mihalic AP, Ahmed AM. The indelible marks on dermatology: Impacts of COVID-19 on dermatology residency Match using the Texas STAR database. Clinics in dermatology 2023. link 44 Ghanian S, Frech FS, Dreyfuss I, Hernandez L, Nouri K. Trends in racial diversity of dermatology residency applicants from 2016 to 2020: a retrospective review study. Archives of dermatological research 2023. link 45 Farooq S, Mehta A. Modeling the Urology Residency Application and Match Process: A Mathematical Argument for Application and Interview Caps. Urology 2023. link 46 Schoppen Z, Morgan HK, Hammoud M, Marzano D, George K, Winkel AF. Applicant Experience in Communication With Residency Programs After the Introduction of Program Signaling. Journal of surgical education 2023. link 47 Maru JA, Wang J, Knight OJ, Tsou BC, Oatts JT, Ross DA et al.. Barriers in Ophthalmology Residency Applications for Students Identifying as Underrepresented in Medicine: A San Francisco Match Analysis. Journal of surgical education 2023. link 48 Johnstone RE, Neely G, Sizemore DC. Artificial intelligence software can generate residency application personal statements that program directors find acceptable and difficult to distinguish from applicant compositions. Journal of clinical anesthesia 2023. link 49 Nathan AS, Cheung AY, Powers K, Stepp WH, Golub JS, Reyes SA et al.. Assessing the Accuracy of Otomatch.com Data for Individuals Applying to Otolaryngology Residency. The Annals of otology, rhinology, and laryngology 2023. link 50 Chang CWD, Thorne MC, Malekzadeh S, Pletcher SD. Two-Year Interview and Match Outcomes of Otolaryngology Preference Signaling. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2023. link 51 Standiford TC, Thorne MC, Chang CWD, Malekzadeh S, Pletcher SD. Impact of the Standardized Interview Offer Date Initiatives: A Survey of Otolaryngology Applicants and Programs. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 2023. link 52 Standiford TC, David Chang CW, Thorne MC, Malekzadeh S, Pletcher SD. Impact of Preference Signaling on Residency Interview Distribution Among Otolaryngology-Head and Neck Surgery Applicants. Journal of surgical education 2023. link 53 Stack TJ, Berk GA, Ho TD, Zeatoun A, Kong KA, Chaskes MB et al.. Racial and Ethnic Bias in Letters of Recommendation and Personal Statements for Application to Otolaryngology Residency. ORL; journal for oto-rhino-laryngology and its related specialties 2023. link 54 Pletcher SD, Chang CWD, Thorne MC, Malekzadeh S, Francis CL, Naemi B et al.. Interview Invitations for Otolaryngology Residency Positions Across Demographic Groups Following Implementation of Preference Signaling. JAMA network open 2023. link 55 Zhang Y, Guo J, Guan F, Song X, Yang Q, Ji X et al.. Guar gum-based multilayer fiber membranes inspired by plant transpiration for enhancing the functionality of dry facial masks. International journal of biological macromolecules 2023. link 56 Khanijahani A, Iezadi S, Agoglia S, Barber S, Cox C, Olivo N. Factors Associated with Information Breach in Healthcare Facilities: A Systematic Literature Review. Journal of medical systems 2022. link 57 Hassan J, Shehzad D, Habib U, Aftab MU, Ahmad M, Kuleev R et al.. The Rise of Cloud Computing: Data Protection, Privacy, and Open Research Challenges-A Systematic Literature Review (SLR). 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Away Rotation Applications in Emergency Medicine: Medical Student Behaviors, Outcomes, and Stressors. The Journal of emergency medicine 2022. link 63 Kukulski P, Schwartz A, Hirshfield LE, Ahn J, Carter K. Racial Bias on the Emergency Medicine Standardized Letter of Evaluation. Journal of graduate medical education 2022. link 64 Dirr MA, Brownstone N, Zakria D, Rigel D. Dermatology Match Preference Signaling Tokens: Impact and Implications. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2022. link 65 Ahmed AM, Helfrich YR. The ERAS Supplemental Application: Current Status and Recommendations for Dermatology Applicants and Programs. Cutis 2022. link 66 Gorgy M, Shah S, Arbuiso S, Cline A, Russo M. Comparison of cost changes due to the COVID-19 pandemic for Dermatology residency applications in the USA. Clinical and experimental dermatology 2022. link 67 Whitley JA, Joyner BD, Asante PG, Waters WB, Kieran K. Exploring Barriers to the Inclusion of Underrepresented Minorities in Urology: The Temporal and Financial Costs of Residency Interviews. Urology 2022. link 68 Friedman BJ, Chen I, Asantey K, Loeb S, Kim SP, Malik RD et al.. Twitter Engagement of Medical Students Applying to Urology Residency During COVID-19: A Mixed Methods Study. Urology 2022. link 69 Carpinito GP, Caldwell KM, Kenigsberg AP, Ganesan V, Khouri RK, Kuprasertkul A et al.. Twitter and Instagram Use in the Urology Residency Application Process. Urology 2022. link 70 Demzik A, Filippou P, Chew C, Reines K, Brown S, Wallen EM et al.. Linguistic Differences in Personal Statements of Urology Residency Applicants by Self-Reported Race and Ethnicity. Urology 2022. link 71 Santos-Parker KS, Hammoud MM, Winkel AF, Marzano D, Frank S, Franz P et al.. Distributions of Residency Interviews With the Implementation of Virtual Interviews and Standardization of Interview Offer Dates. 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    Original source

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