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Psychiatry8 papers

Adjustment disorder with withdrawal

Last edited: 4/10/2026

Overview

Adjustment disorder with withdrawal is characterized by a gradual disengagement from social interactions, potentially leading to isolation 1. This social withdrawal can be an early manifestation of various neuropsychiatric disorders 1.

Diagnosis

  • Social withdrawal is characterized by a gradual disengagement from social interactions 1.
  • Measures of social withdrawal can be derived to assess its severity 1.
  • Management

  • Addressing social withdrawal in the early phases of illness may promote symptom remission 1.
  • Short-term psychopharmacological treatment (12 weeks) is used to assess clinical remission 1.
  • Key Recommendations

  • Higher baseline levels of social withdrawal are associated with a decreased likelihood of short-term remission 1. (Evidence: Moderate)
  • Social withdrawal should be addressed in the early phases of psychiatric disorders to promote symptom remission 1. (Evidence: Moderate)
  • References

    1 Oliva V, Fanelli G, Kasper S, Zohar J, Souery D, Montgomery S et al.. Social withdrawal as a trans-diagnostic predictor of short-term remission: a meta-analysis of five clinical cohorts. International clinical psychopharmacology 2022. link

    Original source

    1. [1]
      Social withdrawal as a trans-diagnostic predictor of short-term remission: a meta-analysis of five clinical cohorts.Oliva V, Fanelli G, Kasper S, Zohar J, Souery D, Montgomery S et al. International clinical psychopharmacology (2022)
    2. [2]
      Withdrawal of treatment: ethical issues.Dalinis P, Henkelman WJ Nursing management (1996)

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